The Drug Interaction Knowledge Base (DIKB) Project
This is the front page for the Drug Interaction Knowledge Base
(DIKB), an evidence-focused knowledge base designed to support
pharmacoepidemiology and clinical decision support. The DIKB contains
quantitative and qualitative assertions about drug mechanisms and
pharmacokinetic drug-drug interactions for over 60 drugs; primarily
psychotropics and HMG-CoA reductase inhibitors (statins).
This project is supported by a grant from the National Library of Medicine: "Addressing gaps in clinically useful evidence on drug-drug interactions" (1R01LM011838-01)
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PUBLICATIONS FROM THE DIKB PROJECT:
- Ayvaz S, Horn J, Hassanzadeh O, Zhu Q, Stan J, Tatonetti NP, Vilar S, Brochhausen M, Samwald M, Rastegar-Mojarad M, Dumontier M, Boyce RD, Toward a complete dataset of drug-drug interaction information from publicly available sources, Journal of Biomedical Informatics. 55 (2015), 206-217. DOI:10.1016/j.jbi.2015.04.006. http://www.sciencedirect.com/science/article/pii/S1532046415000738# PMCID: PMC4464899.
- Pfundner , A., Schönberg, T., Horn., J., Boyce, RD., and Samwald, M. Utilizing the Wikidata system to improve the quality of medical content in Wikipedia in diverse languages: a pilot study. 2015; 17(5). http://www.jmir.org/2015/5/e110/ .
- Brochhausen, M., Schneider, J., Malone, D., Empey, PE., Hogan WR., and Boyce, RD. Towards a foundational representation of potential drug-drug interaction knowledge. The 1st International Drug-Drug Interaction Knowledge Representation Workshop (DIKR 2014). Collocated with the 2014 International Conference on Biomedical Ontology (ICBO 2014). October 6th, Houston, Texas. United States. http://ceur-ws.org/Vol-1309/paper2.pdf.
- Schneider, J., Collins, C., Hines, L., Horn, JR, Boyce, R. “Modeling Arguments in Scientific Papers.” at the 12th Annual ArgDiaP Conference: From Real Data to Argument Mining. Warsaw, Poland, May 23-24 2014. http://jodischneider.com/pubs/argdiap2014.pdf
- Schneider, J., Ciccarese, P., Clark, T., Boyce, RD. Using the Micropublications ontology and the Open Annotation Data Model to represent evidence within a drug-drug interaction knowledge base. The 4th Workshop on Linked Science 2014— Making Sense Out of Data (LISC2014). Collocated with the 13th International Semantic Web Conference (ISWC2014). October 19th and 20th, Riva del Garda, Trentino, Italy. http://ceur-ws.org/Vol-1282/.
- Boyce. RD., Ryan. PB., Noren. N., et al., Bridging islands of information to establish an integrated knowledge base of drugs and health outcomes of interest. Drug Safety. 2014. Volume 37, Issue 8 (2014), Page 557-567. DOI: 10.1007/s40264-014-0189-0, PubMed PMID: 24985530. PMCID: PMC4134480. http://link.springer.com/article/10.1007%2Fs40264-014-0189-0
- Scheife RT, Hines LE, Boyce RD, Chung SP, Momper JD, Sommer CD, Abernethy DR, Horn JR, Sklar SJ, Wong SK, Jones G, Brown ML, Grizzle AJ, Comes S, Wilkins TL, Borst C, Wittie MA, Malone DC. Consensus Recommendations for Systematic Evaluation of Drug-Drug Interaction Evidence for Clinical Decision Support. Drug Saf. 2015 Jan 3. [Epub ahead of print] PubMed PMID: 25556085. [PMCID – in process]. http://link.springer.com/article/10.1007%2Fs40264-014-0262-8
- Hernandez, AM., Hochheiser, H., Horn, J., Jacobson, R., Boyce, RD. Testing Pre-Annotation to Help Non-Experts Identify Drug-Drug Interactions Mentioned in Drug Product Labeling. Panel presentation at Citizen + X: Volunteer-Based Crowdsourcing in Science, Public Health, and Government. A workshop held at the Second AAAI Conference on Human Computation and Crowdsourcing (HCOMP-2014) Pittsburgh, PA. November 2nd, 2014. http://www.aaai.org/ocs/index.php/HCOMP/HCOMP14/paper/viewFile/9259/9187
- Boyce R, Collins C, Horn J, Kalet I. Computing with evidence Part II: An
evidential approach to predicting metabolic drug-drug interactions. J Biomed
Inform. 2009 Dec;42(6):990-1003. Epub 2009 Jun 16. PubMed PMID:19539050; PubMed Central PMCID: PMC2783683.
- Boyce R, Collins C, Horn J, Kalet I. Computing with evidence Part I: A
drug-mechanism evidence taxonomy oriented toward confidence assignment. J Biomed
Inform. 2009 Dec;42(6):979-89. Epub 2009 May 10. PubMed PMID: 19435613; PubMed Central PMCID: PMC2783801.
- Boyce RD, Collins C, Horn J, Kalet I. Modeling drug mechanism knowledge using
evidence and truth maintenance. IEEE Trans Inf Technol Biomed. 2007
Jul;11(4):386-97. PubMed PMID: 17674621.
- Boyce R, Collins C, Horn J, Kalet IJ. Qualitative pharmacokinetic modeling of
drugs. AMIA Annu Symp Proc. 2005:71-5. PubMed PMID: 16779004; PubMed Central
Drug Interaction Knowledge Base (DIKB) by Richard D. Boyce is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.
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