The University of Pittsburgh Pharmacokinetic Drug-drug Interaction (PK DDI) Package Insert Corpus

Description of the resource and download links

This is the download page for the "PK DDI" corpus, a new corpus of sections from FDA-approved drug package inserts (PIs) that have been manually annotated for pharmacokinetic drug-drug interactions by a pharmacist and a drug information expert. The two annotators reached consensus on 592 PK DDIs, 3,351 active ingredient mentions, 234 drug product mentions, and 201 metabolite mentions present in over 200 PI sections extracted from 64 drug PIs. The corpus is provided to the non-profit research community under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Please provide the following citation in any works created or derived from the PK DDI corpus:

• Boyce R, Gardner G, Harkema H. Using Natural Language Processing to Extract Drug-Drug Interaction Information from Package Inserts. Proceedings of the 2012 Workshop on BioNLP. Montreal, Quebec, Canada. June 8, 2012. http://www.aclweb.org/anthology/W/W12/W12-2426.pdf.

• Annotated DDI data in an XML format similar to the one used by the 2013 SemEval challenge corpus
• Annotated DDI data and Knowtator project
• The annotation guidelines used to annotate drug package inserts

• The Drug Interaction Knowledge Base (DIKB)